Excluding PVC from Kubernetes Cluster

I think it is possible to achieve this through the use of labels → https://documentation.commvault.com/11.42/software/excluding_kubernetes_applications_from_application_group.html

As ​@Onno van den Berg implied, yes you should be able to filter PVCs based on a unique label applied only to the PVCs.

It is worth noting that without PVC protection Commvault will only be protecting deployment YAMLs of applications and etcd (if configured).
If PVCs are excluded their persistent data will not be protected. Your OpenShift team are probably aware of this but I’d just like to emphasize it to prevent a scenario where you may not be protected the data you expect.